APOE4, high cholesterol, and why statins might be the wrong "solution" The key insight: It's not how much cholesterol you have - it's what it's doing in your body. My clinical observation: ALL of my APOE4 patients (Alzheimer's gene carriers with one or two alleles) have elevated cholesterol. Sometimes wickedly high. But here's what's important: Unless they're eating a high-glycemic diet, these patients don't develop cardiovascular disease despite high cholesterol numbers. The problem with standa