Plasmodium falciparum ATP4 (PfATP4) is a Na + efflux pump and represents an important target for antimalarial drugs with nanomolar potency. However, the structure of PfATP4 is unknown, prompting the development of new methodologies to ...Among new antimalarials discovered over the past decade are multiple chemical scaffolds that target Plasmodium falciparum P-type …

Commentaries call attention to articles of particular note.. Inaugural Articles may be submitted by newly elected NAS members as a way to introduce themselves to the readers of PNAS and may present new ideas or hypotheses or describe the historical development of the member’s field.View the Inaugural Articles collection.. Front Matter is a magazine section that tells the …

Dec 17, 2024 · Browse the most-recent publications from PNAS, publishing daily across the physical, social, and biological sciences.

Soils are estimated to contribute up to 25% of the potential of natural climate solutions for climate change mitigation, particularly in agricultural croplands ().Aside from the mitigation of climate change, increases in SOC in agricultural ecosystems also enhance soil quality and food security ().The sequestration of SOC in agricultural soil is a hot topic in major policy initiatives and ...

Cover image: Pictured are cattle herders in Ethiopia. A collection of articles in the Sustainability of Animal-Sourced Foods and Plant-Based Alternatives Special Feature explores the contributions of animal-sourced foods to human nutrition and health, the environmental impact of animal-sourced foods, and the potential of plant-based alternatives to help reduce animal-sourced food …

US municipal wastewater facilities are major per- and polyfluoroalkyl substances (PFAS) sources known to affect drinking water quality. Among eight large wastewater treatment facilities with comparable treatment technologies and sizes to those serving 70% of the US population, we found that the six regulated PFAS in drinking water accounted for <10% of extractable …

Liquid–liquid phase separation (LLPS) of proteins and nucleic acids (1–4) is a versatile intracellular process, which leads to the formation of biomolecular condensates (BMCs).The occurrence of LLPS was shown to be a widely spread phenomenon in biology ().The detailed LLPS process and the thus-forming BMCs were first revealed by Brangwynne et al. by …

Nov 8, 2024 · Drylands are vulnerable to both natural and anthropogenic perturbations (13, 18, 19).Land degradation over the past decades or centuries, resulting mainly from intensified human activities (), has led to widespread wind erosion and frequent dust storms in drylands across the world (21–23).Given that 44% of organic matter in the top 30 cm of soil worldwide is stored in …

A PDF list of Editorial Board members and staff members is posted on the current issue Table of Contents; click on the [Masthead (PDF)] link in the upper right corner.

Aug 2, 2024 · Nutrient and moisture limitations reveal keystone metabolites linking ... ... +n