Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide …
Feb 12, 2025 · Skatole is a pungent heterocyclic compound derived from the essential amino acid l-tryptophan by bacteria in the mammalian digestive tract. The four-step anaerobic conversion of tryptophan to skatole is well-established; though, to date, no aerobic counterpart has been …
See results only from pubs.acs.orgMechanistic Studies of a Skatole-Forming Glycyl Radical Enzyme …
Oxidation of skatole in ruminant lungs generates a reactive, electrophilic metabolite that causes fog fever and eventual death by asphyxiation. In h…
Indoleacetate decarboxylase is a glycyl radical enzyme ... - Nature
Oct 11, 2018 · Here, the authors elucidate the final step of skatole biosynthesis, describing the discovery and biochemical characterization of the enzyme catalysing the conversion of …
- Author: Dazhi Liu, Yifeng Wei, Xuyang Liu, Yan Zhou, Li Jiang, Jinyu Yin, Feifei Wang, Yiling Hu, Ankanahall...
- Publish Year: 2018
Mechanistic Studies of a Skatole-Forming Glycyl …
Jun 15, 2022 · Oxidation of skatole in ruminant lungs generates a reactive, electrophilic metabolite that causes fog fever and eventual death by asphyxiation. In humans, gut bacterial-derived skatole is a pulmonary and hepatic toxin.
- Studies of Skatole Biosynthesis
Skatole - Wikipedia
Skatole is derived from the amino acid tryptophan in the digestive tract of mammals. Tryptophan is converted to indoleacetic acid, which decarboxylates to give the methylindole. Once it is created in the digestive tract of mammals, it is metabolized by cytochrome P450 enzymes in the liver.
Skatole can be synthesized via the Fischer indole synthesis.
It gives a violet color upon treatment with potassium ferrocyanide.Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 7 mins
Herein, we report the discovery of the oxygen-dependent skatole synthase SktA that single-handedly converts 5-bromo-L-tryptophan to 5-bromoskatole, obviating the need for a …
Indoleacetate decarboxylase is a glycyl radical enzyme catalysing …
Skatole is a bacterial metabolite responsible for boar taint and the objectionable smell of manure. Here, the authors elucidate the final step of skatole biosynthesis, describing the discovery and …
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Molecular Analysis of Indole and Skatole …
Aug 29, 2024 · Biodegradation was considered a feasible method for the removal of indole and skatole, but a comprehensive understanding of the metabolic pathways under both aerobic and anaerobic conditions was lacking, and the …
Catabolic Pathway for the Production of Skatole and Indoleacetic …
Jan 25, 2008 · Microorganisms in swine manure produced skatole and other oxidation products from tryptophan, but IAA yielded only skatole. A catabolic mechanism for the synthesis of …
Skatole: A thin red line between its benefits and toxicity
May 1, 2023 · Specifically, two-step skatole synthesis is mediated by different bacterial strains (see more below in ‘Skatole forming microbiota’), the simultaneous presence of which is …
Skatole - Wikiwand
Biosynthesis, chemical synthesis, and reactions. Skatole is derived from the amino acid tryptophan in the digestive tract of mammals. Tryptophan is converted to indoleacetic acid, …
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