Apoptosis is a multi-step, multi-pathway cell-death programme that is inherent in every cell of the body. In cancer, the apoptosis cell-division ratio is altered. Cancer treatment by chemotherapy and irradiation kills target cells primarily by inducing apoptosis. [98]

Jun 6, 2017 · Apoptosis is a process that occurs in multicellular when a cell intentionally “decides” to die. This often occurs for the greater good of the whole organism, such as when the cell's DNA has become damaged and it may become cancerous.

In multicellular organisms, cells that are no longer needed or are a threat to the organism are destroyed by a tightly regulated cell suicide process known as programmed cell death, or apoptosis. Apoptosis is mediated by proteolytic enzymes called caspases, which trigger cell death by cleaving specific proteins in the cytoplasm and nucleus .

Dec 18, 2023 · Regulated cell death mediated by dedicated molecular machines, known as programmed cell death, plays important roles in health and disease. Apoptosis, necroptosis and pyroptosis are three...

The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered a vital component of various processes including normal ...

Apoptosis is an essential process regarding tissue homeostasis, and it eliminates superfluous cells in multicellular organisms. Several signaling pathways contribute to apoptosis, with the intrinsic (mitochondrial) and extrinsic (death receptor) pathways being the main ones.

Mar 30, 2021 · Here, we summarize the latest discoveries in the three most well understood modalities of cell death, namely, apoptosis, necroptosis, and pyroptosis, highlighting common and unique pathways and...

Sep 13, 2024 · Apoptosis is the normal, planned death of damaged cells in your body. It’s an important process that helps keep you healthy. But when it happens too often or not often enough, you can develop problems like cancer or Alzheimer’s disease. Researchers are exploring drugs that can manage apoptosis in your body to treat various conditions.

4 days ago · Apoptosis is the process of programmed cell death. It is used during early development to eliminate unwanted cells; for example, those between the fingers of a developing hand. In adults, apoptosis is used to rid the body of cells that have been damaged beyond repair. Apoptosis also plays a role in preventing cancer.

Apr 30, 2024 · Many years later, apoptosis is defined as the ATP-dependent, enzyme-mediated, genetically programmed death of cells that are either no longer required or pose a threat to the organism. Apoptosis results when the cytoskeleton (by proteases) and DNA (by endonucleases) break down through several pathways that are homeostatic or pathological.