JEV virions contain a positive-sense single-stranded ribonucleic acid (+ssRNA) genome of approximately 11 kb encoding three structural proteins (SPs) (the capsid, membrane/premembrane, and envelope proteins) and seven non-structural proteins (NSPs) (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5).

Feb 15, 2012 · Japanese encephalitis virus (JEV) is the leading global cause of viral encephalitis. The JEV envelope protein (E) facilitates cellular attachment and membrane fusion and is the primary target of neutralizing antibodies. We have determined the 2.1-Å resolution crystal structure of the JEV E ectodomain refolded from bacterial inclusion bodies.

Jun 26, 2017 · Japanese encephalitis virus, Vero cell, membrane protein, heat shock protein 90β, binding. Japanese encephalitis (JE) is an acute and severe viral infection of the human central nervous system that is caused by JE virus (JEV) and is transmitted between animal hosts and humans by mosquitoes (mostly of the genus ) ( 1 ).

Japanese encephalitis virus (JEV) is the leading global cause of viral encephalitis. The JEV envelope protein (E) facilitates cellular attachment and membrane fusion and is the primary target of neutralizing antibodies.

Mar 1, 2016 · Japanese encephalitis virus (JEV) membrane (M) protein plays important structural roles in the processes of fusion and maturation of progeny virus during cellular infection. The M protein is anchored in the viral membrane, and its ectodomain is composed of a flexible N-terminal loop and a perimembrane helix.

May 30, 2020 · Architecturally, the viral surface network is organized by two proteins, membrane and envelope (M and E) proteins, and due to exposure in host environment, E protein is mostly responsible for generating counter antibodies making it a potential drug target [].

Apr 26, 2017 · Here, we report the cryo-electron microscopy structure of mature Japanese encephalitis virus at near-atomic resolution, which reveals an unusual “hole” on the surface, surrounded by five...

Oct 1, 2021 · All flaviviruses, including JEV replicate in close association with ER derived membranes by channelizing the protein and lipid components of the ER. This leads to activation of acute stress responses in the infected cell-oxidative stress, ER stress, and autophagy.

Nov 1, 2020 · For a better understanding of the mechanism of attenuation of Japanese encephalitis virus (JEV), in this study, we assessed whether prM/E is critical neurovirulence determinants of JEV with infectious cDNA clones technique.

Japanese encephalitis virus (JEV) (family Flaviviridae, genus Flavivirus) is a single-stranded, positive-sense RNA virus with a genome size of approximately 11 kb.