Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract illness in young children. 1, 2, 3, 4 So effectively does RSV spread that essentially all persons have experienced RSV infection within the first few years of life. Immunity, however, is …

Mar 1, 2002 · Both the innate and adaptive arms of the cellular immune system are involved in the immunological response to RSV. The cytopathic effects of the virus explain many of the pathological findings in RSV disease. However, there is compelling evidence to suggest that the host cell immune response also has a prominent role in disease pathogenesis.

In several common cell culture lines for the propagation and study of RSV (HEp-2, Vero, A549 cells) and in airway epithelial cultures, RSV A2 is generally associated with higher replication kinetics and more cytopathic effects earlier in infection when compared to other “laboratory” or clinical isolates [42,81,82,83].

Human respiratory syncytial virus (RSV) is recognized as the most important cause of ALRI in infants worldwide. It is estimated that every year 33.8 million new cases of RSV-related ALRIs occur and cause approximately 200,000 deaths in children younger than 5 years; of note, 99% of these deaths occur in developing countries.

Mar 1, 2013 · RSV pathogenesis in human airway tissues and AECs. Cytopathic effects of RSV in human airway tissues have been observed in histological studies of lung tissue from fatal cases of RSV infection, indicating that human bronchial, bronchiolar and alveolar epithelium are the main targets for RSV infection [12], [13].

RSV has a direct cytopathic effect on cells in the lung epithelium, leading to loss of specialized functions such as cillial motility and sometimes to epithelial destruction ( ).

Jan 27, 2011 · To address this hypothesis, we isolated three RSV strains from infants hospitalized with bronchiolitis and compared them with the prototypic RSV A2 in terms of cytopathology, virus growth kinetics and chemokine secretion in infected PBEC monolayers. RSV A2 rapidly obliterated the PBECs, whereas the clinical isolates caused much less cytopathology.

The cytopathic effects of the virus explain many of the pathological findings in RSV disease. However, there is compelling evidence to suggest that the host cell immune response also has a prominent role in disease pathogenesis.

Mar 14, 2022 · Perhaps consistent with their greater permissibility, confocal imaging revealed a greater cytopathic effect in RSV-infected HEp-2 than A549 cells at later time points (72 and 96 hpi).

RSV grows to moderate titers in HAE, though they are significantly lower than those in a continuous epithelial cell line, HEp-2. In HAE, RSV spreads over time to form focal collections of infected cells causing minimal cytopathic effect.