The Panel on Antiretroviral Guidelines for Adults and Adolescents (the Panel) now recommends initial ARV regimens based on an oral second-generation INSTI plus two NRTIs—bictegravir (BIC)/tenofovir alafenamide (TAF)/‌emtricitabine (FTC) (AI) or dolutegravir (DTG) plus TAF/FTC or tenofovir disoproxil fumarate (TDF)/ FTC or TDF/lamivudine (3TC) (A...

Jan 1, 2018 · Update on recommendations on antiretroviral regimens for treating and preventing HIV infection: In 2016, WHO published the consolidated guidelines on the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and recommended tenofovir disoproxil fumarate (TDF) + lamivudine (3TC) (or emtricitabine, FTC) + efavirenz (EFV) 600 ...

These guidelines provide further reassurance of DTG as the preferred antiretroviral (ARV) drug in first-and second-line regimens due to the declining estimate of neural tube defect risk and observed efficacy.

Sep 12, 2024 · Antiretroviral Regimen Considerations for Initial Therapy Based on Specific Clinical Scenarios. This table guides clinicians in choosing an initial antiretroviral (ARV) regimen according to various patient and regimen characteristics and specific clinical scenarios.

New WHO interim guidelines contain recommendations regarding preferred first-line regimens for adults, adolescents and children initiating ART, which now include DTG and RAL (Box 1). BOX 1. RECOMMENDATIONS: FIRST-LINE ARV DRUG REGIMENS 1. A DTG based regimen may be recommended as a preferred first-line regimen for people living with

Dec 7, 2022 · In this webinar, a panel of world-class experts discussed what South Africa’s updated guidelines for how we use ARVs may look like.

4 days ago · The impact of the initial freeze extended far beyond the provision of ARVs. The suspension of PEPFAR, which supports over 20 million people on antiretroviral treatment worldwide, raised alarm bells globally. In South Africa alone, PEPFAR contributed approximately 17% of the R44.4-billion spent on the country’s massive HIV counselling and ...

The emergence of new ARVs with a higher barrier against resistance and more potent antiretroviral activity has led to more interest in reducing ART to 2-drug regimens (2DRs). Several clinical trials and observational studies have shown good virologic and immunologic efficacy of …

Jul 27, 2023 · LA-ARVs showed favorable safety profiles for both the prevention and treatment of HIV-1 infection and were well tolerated. CAB-LA has more satisfactory efficacy than tenofovir disoproxil fumarate-emtricitabine, significantly reducing the rate of HIV-1 infection.

For infants not exposed to ARVs, start ART with nevirapine (NVP) + 2 nucleoside reverse transcriptase inhibitors (NRTIs). For infants exposed to maternal or infant NVP or other NNRTIs used for maternal treatment or PMTCT, start ART with lopinavir/ritonavir (LPV/r) + 2 NRTIs.