A new study found that aged neurons have defects in key proteins that make them vulnerable to molecular stress and neurodegenerative damage.

Well-established industry leader whose oncology expertise and transactions record has led to multiple approved therapeutic ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

A specialised molecular complex known as the minor spliceosome removes some rare but critical introns, and several genetic disorders are associated with its dysfunction. The Galej Group at EMBL ...

How does the cell select this information? A large molecular machine called the spliceosome constinuously separates the coding and non-coding regions of our genes – and it’s doing this even as you ...

How does the cell select this information? A large molecular machine called the spliceosome continuously separates the coding and non-coding regions of our genes – and it's doing this even as ...

Almost half of mutation carriers were symptomatic. In people with symptomatic FTD, synaptic and lysosomal proteins were down compared with controls, while RNA-processing spliceosome proteins were up.

Structural biologists provide a first-time look at the atomic level into the quality control mechanism of this complex molecular machine A complex molecular machine, the spliceosome, ensures that ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA.

"Our algorithm attempts to recognize these donor/acceptor sites in pairs, just as a spliceosome 'molecular machine' does in the cell when it cuts out an intron," says Chao. The researchers developed ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona, a BIST Community centre, have created the first blueprint of the human spliceosome, the most complex and intricate molecular ...