A new study found that aged neurons have defects in key proteins that make them vulnerable to molecular stress and neurodegenerative damage.

This and related inhibitors will not only be useful as tools to decipher the roles of the individual components of the spliceosome but may also serve as therapeutics. Using small molecules or ...

For many eukaryotic introns, splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and associated proteins ...

As a research associate scientist, he cloned and characterized numerous RNA-RNA interactions of the minor spliceosome. His work was the first to demonstrate the conservation of the minor ...