This is the second of a two-part note, which covers: * What are GLP-1 receptor agonists? * Which were the first GLP-1s approved for type 2 diabetes (T2D)? When were they approved? Who makes them? Are ...

This is the first of a two-part note, which covers: * What are GLP-1 receptor agonists? * Which were the first GLP-1s approved for type 2 diabetes (T2D)? When were they approved? Who makes them? Are ...

* Last week's note reviewed a Korean population study, which led to headlines such as " Taking statins could slash dementia risk." The claims were not robust. * This week's note reports findings from ...

* On March 5th, 2025, headlines in the mainstream media reported “NHS ‘should give all over-50s statins’” and “NHS should offer ‘polypill’ to cut heart disease, experts urge.” * The headlines came ...

* This is the second of a two part note looking at metabolism. * Benedict is credited as the first person to study the impact of a calorie deficit in human beings (1917). * Benedict’s research took ...

* This week’s note contains a podcast with Hannah Sutter and research about ketogenic diets for epilepsy. Hannah is particularly interested in (and provides food for) the ketogenic diet for epilepsy – ...

This is the 700th Monday note. In this landmark post, I share the key things that I have learned over the past 14 years ...

* I read a book called “Burn: The misunderstood science of metabolism” by Dr Herman Pontzer. Pontzer had lived with and studied the Hadza – a modern hunter-gatherer people living in northern Tanzania.

This note goes through the basics of the case: who, when, what, defamation law, the defence put forward by the Defendants, the summary Judgment and what this case was and wasn’t about. I will quote ...

* This week's note was inspired by a podcast I did where I described olive oil as "not all that." * It opens with the basic facts about fat. * It then looks at olive oil, which is 100% fat (mostly ...

* This week's note looks at a paper about animal and vegetable protein intake and malnutrition in older adults. * The paper claimed that "Higher animal and, especially, vegetable protein intake were ...

I recently needed to look up how much the main statin, Lipitor, had earned during its lifetime. This led me to a useful and interesting chart, which reported the top 10 blockbuster drugs by global ...