In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi ...

An 11-year-old girl with eczema was evaluated for chest pain and arm pain. Imaging showed multiple bone and liver lesions. The erythrocyte sedimentation rate was higher than 130 mm per hour. A diag ...

A previously healthy 44-year-old man presented with a 4-day history of an itchy rash and a 2-day history of fever and malaise. A pleomorphic eruption of papules and pustules of different sizes and ...

Idiopathic normal-pressure hydrocephalus is a neurologic disorder characterized by impaired gait, balance, cognition, and ...

In this phase 3, multinational, randomized, double-blind trial, we examined the safety and efficacy of once-daily orforglipron at doses of 6 mg, 12 mg, or 36 mg, as compared with placebo (assigned in ...

Tobacco use kills more than 7 million people worldwide each year, including 1.3 million who die from the effects of exposure to secondhand smoke.1 As a major contributor to cancer, cardiovascular ...

There is an urgent need for low- and middle-income countries to ensure equitable, affordable, and sustained access to tobacco-cessation medications at scale.

Christopher Duggan is the director of the Center for Nutrition at Boston Children’s Hospital, a professor of pediatrics at Harvard Medical School, and a professor in the Departments of Nutrition and ...

Hypertrophic cardiomyopathy (HCM) is a complex, heterogeneous disorder that directly affects only the heart. It is characterized by hypertrophy of any portion of the left ventricular wall, frequently ...

The author describes the scientific foundations of a clinical trial of a first-in-class small-molecule estrogen receptor degrader to treat patients with metastatic breast cancer.

The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle, ...