Increased renin gene expression along with hypertrophy of JGCs is found during long-term, enhanced renin release. In addition to the hypertrophy of juxtaglomerular cells, the abovementioned ...

Background Orthostatic intolerance occurs following immobilization in patients on Earth and in astronauts after spaceflight. Head‐down tilt bedrest is a terrestrial model for weightlessness and ...

Cardiovascular disease (CVD) remains a major health burden despite significant therapeutic advances accomplished over the last decades. It is widely and increasingly recognized that systemic ...

Obesity is a significant risk factor for heart failure (HF) development, particularly HF with preserved ejection fraction and as a result, many patients with HF also have obesity. There is growing ...

Background To study the age‐adjusted Charlson comorbidity index (ACCI) scale, which is a comprehensive quantification of multimorbidity coexistence, for the assessment of the risk of acute myocardial ...

This narrative review discusses the genetic determinants of plasma lipoprotein(a) levels and explores the factors that influence interindividual heterogeneity, including single‐nucleotide ...

Fibroblasts are essential for building and maintaining the structural integrity of all organs. Moreover, fibroblasts can acquire an inflammatory phenotype to accommodate immune cells in specific ...

Wildfire smoke (WFS) is a mixture of respirable particulate matter, environmental gases, and other hazardous pollutants that originate from the unplanned burning of arid vegetation during wildfires.

Abstract Mammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as ...

Abstract The impacts of accumulating atmospheric greenhouse gases on the earth’s climate are now well established. As a result, there have been increases in ambient temperatures and resultant higher ...

Impaired arterial health is associated with a decline in cognitive function and psychopathology in adults. We hypothesized that these associations originate in early life. We examined the associations ...

Background Stent thrombosis is a rare but deleterious event. Routine coronary angiography with percutaneous coronary intervention (PCI) is often deferred in the presence of laboratory markers of acute ...