eLife2d
Large inversions in Lake Malawi cichlids are associated with habitat preference, lineage, and sex determination
Chromosomal inversions are an important class of genetic variation that link multiple alleles together into a single inherited block that can have important effects on fitness. To study the role of ...
eLife2d
Methylation Clocks Do Not Predict Age or Alzheimer’s Disease Risk Across Genetically Admixed Individuals
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. Cruz-González and ...
eLife2d
Methylation Clocks Do Not Predict Age or Alzheimer’s Disease Risk Across Genetically Admixed Individuals
Epigenetic clocks that quantify rates of aging from DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), ...
eLife2d
Expanding Automated Multiconformer Ligand Modeling to Macrocycles and Fragments
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. Flowers et al describe an improved version of qFit-ligand, an ...
eLife2d
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark Department for Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark Department of ...
eLife2d
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. Zacharia and ...
eLife2d
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
The C-terminal TPRs of IFT172 constitute a binding site for IFT-A subunits. (A) Schematic representation of Homo sapiens (Hs) IFT172 protein domain organization. β-propeller and TPR (tetratricopeptide ...
eLife2d
Molecular Feature-Based Classification of Retroperitoneal Liposarcoma: A Prospective Cohort Study
This study presents a valuable and simplified classification system for predicting clinical outcomes in RPLS patients. The evidence supporting the claims of the authors is solid, although the ...