Objective To assess the efficacy and safety of the type I interferon receptor antibody, anifrolumab, in patients with active, biopsy-proven, Class III/IV lupus nephritis. Methods This phase II ...

Objectives To provide an update of the EULAR rheumatoid arthritis (RA) management recommendations addressing the most recent developments in the field. Methods An international task force was formed ...

Objective Increasing evidence suggests that impaired cartilage is a substantial risk factor for the progression from hyperuricaemia to gout. Since the relationship between cartilage matrix protein and ...

Background NeceSSity stands for “New Clinical Endpoints in primary Sjögren’s Syndrome: an Interventional Trial based on stratifYing patients”. International consortium involving 25 partners (20 ...

Correspondence to Dr Tristan Maerz, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA; tmaerz{at}med.umich.edu Objectives Synovium is acutely affected following joint ...

Correspondence to Dr Annette H M van der Helm-van Mil, Department of Rheumatology, Leiden University Medical Center, P.O. Box 9600, Leiden 2300 RC, The Netherlands; AvdHelm{at}lumc.nl Background ...

Background Janus kinase (JAK) inhibitors have been recognized as a potential therapeutic option in ankylosing spondylitis (AS), also known as radiographic axial spondyloarthritis (r-axSpA). 1 ...

Objectives To investigate how individual rheumatoid arthritis (RA) autoantibodies associate with individual signs and symptoms at the time of RA diagnosis. Methods IgA, IgG, IgM rheumatoid factor (RF) ...

Objectives To identify the arthritogenic B cell epitopes of glucose-6-phosphate isomerase (GPI) and their association with rheumatoid arthritis (RA). Methods IgG response towards a library of GPI ...

Background Attempts to stop glucocorticoids (GC) among lupus patients in long term remission have been successful. Continuing other immunosuppressive (IS) agents indefinitely is currently the norm and ...

1 Hospital for Special Surgery, Rheumatology, New York, United States of America 2 Weill Cornell Medicine, Internal Medicine, New York, United States of America 3 Montefiore Medical Center, Internal ...

Background: Assessment of serum procalcitonin (PCT) levels is of great interest in rheumatology in the diagnosis of infections, including infectious complications during active immunosuppressive ...