Preview the Sept. 27 matchup between the Penn State Nittany Lions and Oregon Ducks with predictions, odds, over/under, spread, betting lines and more.

Oregon, meanwhile, retooled after losing several key players to the NFL but hasn't missed a beat. The Ducks are 4-0, outscoring opponents 203-37. Last week, quarterback Dante Moore carved up rival Oregon State for 305 yards and four touchdowns in a 41-7 rout.

As the Nittany Lions host the Ducks under the lights, Franklin's troubling 1-13 record against top-five teams looms large over a crucial Big Ten showdown

Since Drayton arrived at Penn State early this year, he has worked with Singleton on open-field running and how to elude would-be tacklers. According to Drayton and head coach James Franklin, that has resulted in Singleton not playing free and easy.

Reporters from OregonLive and PennLive answer key questions ahead of Saturday's game between No. 6 Oregon and No. 3 Penn State.

Find single game tickets to the Penn State Nittany Lions vs. Oregon Ducks college football Week 5 matchup on Saturday, September 27, 2025.

The Razorbacks led 28-10 late in the first half last Saturday and lost 32-31 after they committed red-zone turnovers on two of their last three series. Arkansas' first loss to a non-power conference team since 2022 dropped Pittman to 32-33 in six seasons.

Out of all they keys to Penn State's game plan, they have to figure this one out. It's nice to have a kicker like Ryan Barker on your team, but it's not nice that he has kicked 10 field goals over your first three games.