While Tarik Skubal is well on his way to his second straight AL Cy Young award, Philly's Zack Wheeler and Pittsburgh's Paul Skenes are neck-and-neck in the NL.

With a full slate of MLB games all set to get underway this weekend, pitchers’ strikeout bets are up and running. Some of the best pitchers are lined up to have a strong outing as they take on their rivals.

Check out all of our starting pitcher rankings and other lineup selection tools here to help you make smart fantasy baseball lineup decisions. MLB betting tips for each day's slate of games will also be added in the morning. MLB game odds are provided by ESPN BET, and all fantasy advice is geared toward ESPN 10-team leagues with standard scoring.

Coming off of a historic game on Friday night in which he became the f irst Major League Baseball rookie to hit four home runs, the general public has been introduced to Athletics rookie first baseman Nick Kurtz. This is coming off a week where the 22-year-old Kurtz was named the AL Player of the Week. The betting market has taken notice as well.

SportsLine's Mike McClure, a daily Fantasy pro with over $2 million in winnings, gives optimal MLB DFS lineup advice for Friday, July 25

Play-by-play action for the Philadelphia Phillies vs. New York Yankees MLB game from July 27, 2025 on ESPN.