The most important name on the list for the Jaguars is starting wide receiver Dyami Brown, who left last week's game vs. the Houston Texans with a shoulder injury and did not return. After missing practice on Wednesday, Brown was limited on Thursday and Friday and seems like he has a solid chance of playing.

Defensive coordinator Robert Saleh of the San Francisco 49ers talks with Fred Warner during the game against the Seahawks at Lumen Field on Sept. 7, 2025, in Seattle.

Jacksonville Jaguars head coach Liam Coen responded to comments from San Francisco 49ers defensive coordinator Robert Saleh regarding Jacksonville legally stealing signals of opposing defenses.

It wouldn't be a normal San Francisco 49ers injury report without several starters being in question. Surprisingly, Brock Purdy isn't one of them. Kyle Shanahan

Find out how to watch San Francisco 49ers vs. Jacksonville Jaguars live streaming online, plus TV channel and game info for this week 4 NFL matchup.