South Park has seemingly reacted to Kristi Noem’s criticism of the animated series after the Comedy Central show spoofed her. On the most recent episode of South Park, Noem is portrayed as someone heavily invested in her looks, with a whole glam team prepping her hair and makeup. The animated series pokes fun at this …

The homeland security secretary decided to act like the insulting portrayal on "South Park" was just an inverted compliment.

In the episode, South Park Elementary guidance counselor Mr. Mackey gets fired due to the government "cutting back on unnecessary expenses" — a reference to the Trump administration and the Department of Government Efficiency's (DOGE) extensive cuts across the government.