The No. 8 Florida State Seminoles play their first ACC game of the season against the Virginia Cavaliers on Friday, Sept. 26.

Let's take a look at five of the marquee matchups for Week 5, with odds at DraftKings Sportsbook as of Sept. 26. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports)

Welcome back to our weekly article predicting which college football coaches, if any, are most likely to be fired following a potential poor result this weekend

It's not surprising that FPI doesn't have a rosy outlook on what's to come over the next couple months for the Gators.

The changing tides of college football have quickly eroded Oregon State's competitive footing. Just three years removed from beating No. 10 Oregon 38-34 in a Pac-12 thriller, the Beavers are floundering amid conference realignment and have dropped three straight against the Ducks. Oregon dominated its rival 41-7 last week as the Beavs fell to 0-4.

The Florida Gators face a decision about Billy Napier's future, and one long-shot candidate has emerged as a potential option to be the next head coach in Gainesville.

Miami is the favorite to win the ACC at +125 and is favored to make the 12-team playoff (-300). The Hurricanes are on bye this week before meeting Florida State in Tallahassee, which appears to be Miami’s last top-level test of the regular season.

Florida’s star sophomore quarterback, DJ Lagway, has not progressed this season as expected. He has a completion rate of 67.5%, throwing for 690 yards, with five touchdowns and six interceptions. In his last two games, he has recorded 348 passing yards, one touchdown and five interceptions.