Manzano is taking the Chargers so seriously, he ranked Jim Harbaugh's club at No. 2 overall behind only the defending Super Bowl champion Philadelphia Eagles. The Tampa Bay Buccaneers, San Francisco 49ers and Indianapolis Colts followed No. 3 Buffalo in that order.

This isn't the week for Spencer Rattler to throw 40 times, but the Saints passing offense must still make plays. Breaking down their Bills matchup:

Bills rookie Jackson Hawes has a 91.8 PFF grade, the highest of any tight end in the NFL. He’s also the league’s top-graded rookie after three weeks.

Bills remain near the top of NFL rankings despite missing key defensive players like Matt Milano and Ed Oliver, with most outlets keeping them second behind Philadelphia.

NFL Week 4 odds, picks, predictions, TV channel, streaming information for the Sunday football game between the New Orleans Saints and Buffalo Bills.

The Buffalo Bills were named a suitor for an explosive wideout, but shouldn't be interested in making the move.

Buffalo Bills' second year wide receiver Keon Coleman says that the New Orleans Saints' defense presents "no challenges" in Week 4.