Manzano is taking the Chargers so seriously, he ranked Jim Harbaugh's club at No. 2 overall behind only the defending Super Bowl champion Philadelphia Eagles. The Tampa Bay Buccaneers, San Francisco 49ers and Indianapolis Colts followed No. 3 Buffalo in that order.

On paper, the Bills’ matchup with the Saints is a huge mismatch. New Orleans has holes all over their roster, which the Seahawks exposed frequently in Week 3. Considering how Buffalo is widely believed to be a better team than them, that means this game could get ugly if they come out and play their brand of football from the get-go.

How do you see this one playing out? The New Orleans Saints and Buffalo Bills are set to kick off in Week 4, and our staff writers predict a bloodbath

We searched high and low for a brave soul who picked the New Orleans Saints to beat the Buffalo Bills on Sunday.

The Buffalo Bills head into Week 4 of NFL action undefeated, now set to face a rather downtrodden team in the New Orleans Saints. The last things the Bills should do is treat an opponent they rare see as an afterthought,

To celebrate the Bills Rivalries game, Wegmans will be selling limited edition Bills items in their stores.In August, the team revealed their “cold front” uniforms for their game against the Patriots on Sunday,

About receiving prospects Keon Coleman, Khalil Shakir, Elijah Moore and Josh Palmer. And even about Stefon Diggs.MORE: Josh Allen and Bills have whopping advantage over Saints in talent & travelWhile the former four-time Pro Bowl star struggles with his second team in two seasons - first the Houston Texans,

Dorian Williams will start again for Milano, and with the Bills utilizing more three-linebacker sets this year, that means veteran Shaq Thompson - who has battled a hamstring injury since training camp - will get extra reps. Last week against Miami he played 21 snaps.