The Arizona Wildcats and Iowa State Cyclones meet in a Week 5 Big 12 clash Saturday at Jack Trice Stadium in Ames, Iowa.

The Iowa State Cyclones passing game against the Arizona Wildcats pass defense will be a key to keep an eye on.

Preview the Sept. 27 matchup between the Iowa State Cyclones and Arizona Wildcats with predictions, odds, over/under, spread, betting lines and more.

The Arizona Wildcats and Iowa State Cyclones meet for the first time since 1968, now Big 12 opponents and both coming off open dates.

Arizona is gearing up for its game against No. 14 Iowa State and has seen the first availability report of the season released.

Learn which TV channel or how to live stream the Iowa State Cyclones vs. Arizona Wildcats game, Saturday, Sept. 27.