Mast cells contain granules packed with over 200 signaling chemicals including histamine, prostaglandins, leukotrienes and cytokines. When functioning properly, they release these substances in ...

Jeff Hersh, Ph.D., M.D., can be reached at DrHersh@juno.com. This article originally appeared on MetroWest Daily News: Dr. Hersh: Mast cell activation syndrome can cause numerous symptoms ...

Mast cell activation syndrome (MCAS) is a condition where the mast cells are inappropriately triggered. Primary MCAS is due to a mutation in the mast cells themselves (typically in the KIT gene ...

Depending on one's perspective, "mast cell activation syndrome (MCAS)" is either a relatively rare, narrowly defined severe allergic condition or a vastly under-recognized underlying cause of ...

HARRIS: Mast cells are found throughout the body, and they make histamine. The mast cell activation syndrome is caused by the release of excessive amounts of histamine from those mast cells.

Ollig J, Kloubert V, Taylor KM, Rink L. B cell activation and proliferation increase intracellular zinc levels. J Nutr Biochem. 2019;64:72-79. doi: 10.1016/j.jnutbio.2018.10.008 ...

Mast cells have been around since before the adaptive immune system developed in mammals 500 million years ago. But for such an old cell, we know relatively little about what it does.

An exhaustive resource about MCAS is Lawrence Afrin MD’s 2016 book, Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemic of Chronic Illness and Medical Complexity.

Toll-like receptor 2 (TLR2) and TLR4 are pattern-recognition molecules with an important role in the early innate immune response to microbial challenge, but their presence on mast cells remains ...

Mast cell activation syndrome (MCAS) is a condition where the mast cells are inappropriately triggered. Primary MCAS is due to a mutation in the mast cells themselves (typically in the KIT gene ...

An exhaustive resource about MCAS is Lawrence Afrin MD’s 2016 book, Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemic of Chronic Illness and Medical Complexity.