Methods APRIL and BAFF gene expression was assessed in published transcriptional datasets from healthy donors and SLE patients. PBMCs from healthy donors were stimulated with CD40L, IL-21, BAFF, and ...

The structure−activity relationship (SAR) of a novel hydrophobic binding interaction within a subsite of the influenza neuraminidase (NA) active site was characterized and optimized for a series of ...

In gastric cancer, PD-1/PD-L1 blockade success depends on the expression level of the immune checkpoints. This study reports that METTL3 mediates the m6A modification of PD-L1 and the inhibition of ...

Avian influenza, also called avian flu or bird flu, is an illness that usually affects only birds. There are many different strains of avian flu: 16 H subtypes and 9 N subtypes.

Long-term follow-up of real-world adjuvant anti-PD1 checkpoint inhibition and targeted therapy in stage III melanoma patients. JCO 0 , 10.1200/JCO-24-02776 DOI: 10.1200/JCO-24-02776 ...

On Monday, JMP Securities sustained its Market Outperform rating and $47.00 price target for Cidara Therapeutics (NASDAQ: CDTX) stock, significantly above the current trading price of $21.68 ...

When less is more: How inhibition shapes learning and spatial memory formation by Jerry Grillo, Georgia Institute of Technology edited by Gaby Clark , reviewed by Robert Egan ...

Key points In 2024 in the United States, avian influenza A(H5N1) clade 2.3.4.4b was detected for the first time in dairy cattle, an unexpected and previously unrecognized host, with subsequent ...

Camizestrant plus CDK4/6 inhibition improved PFS vs standard care in patients with ER+/HER2– advanced breast cancer and emergent ESR1 mutations. The median investigator-assessed progression-free ...

Some nanozyme-based detection methods for antioxidants often rely on the direct decolorization of colorimetric substrates by corresponding antioxidants, which weakens the role of nanozymes. Here, CeO2 ...