GBA1 mutations impair ciliary Hedgehog signaling in Parkinson's disease, reducing neuroprotective factors and highlighting a ...

Sterols are beneficial plant metabolites with proven human health effects. In rapeseed (Brassica napus), enhancing sterol content could add significant nutritional value to edible oils.

Keep the cool feeling: A lipid enzyme for maintaining cool temperature sensation and avoidance Date: May 30, 2025 Source: National Institutes of Natural Sciences Summary: Researchers have ...

We found that nuclear envelope-associated lipid droplets (NE-LDs) were enriched in cholesteryl esters compared to lipid droplets in the cytoplasm. Correlative light-volume-electron microscopy revealed ...

Cholesterol, the most abundant sterol molecule in mammalian organisms, serves not only as a fundamental structural component of cell membranes but also as a critical regulator of cellular signaling ...

This study aimed to evaluate the cholesterol-regulatory effects of lauric-acid-esterified octacosanol (LEO) and oleic-acid-esterified octacosanol (OEO) compared to their unmodified counterparts and to ...

mRNA lipid nanoparticles (LNPs) are a powerful technology that are actively being investigated for their ability to prevent, treat, and study disease. However, a major limitation remains: achieving ...

Mana's lung-targeting AI model initially yielded a highly-specific, lung-tropic LNP Iterative in-silico / in-vitro cycles improved in-vivo potency by ~100X in 3-months Data seamlessly translated from ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids -- key ingredients in lipid nanoparticles (LNPs), the molecules behind the ...