New research reveals how breaking down stored glucose (glycogen) in the brain may reduce toxic protein buildup linked to ...

A groundbreaking study reveals that reshaping nuclear speckles — tiny structures inside cell nuclei that regulate protein maintenance — could be a novel way to treat proteinopathies like Alzheimer’s, ...

Tau protein in Parkinson's disease Parkinson’s disease (PD) is the second most common neurodegenerative disease, primarily characterized by the abnormal aggregation of α-synuclein (α-syn) into ...

Feb 20, 2022 3:52 pm · Updated Feb 21, 2022 11:12 am ...

The neurotransmitter glutamate is essential for regulating everything from mood to memory, but it can also encourage a toxic buildup of protein, which can contribute to Alzheimer’s and related ...

This argues that mutations in Tau may reduce the protein's normal ability to prevent oxidative stress in addition to causing the protein to accumulate into the typical hallmarks of disease, as ...

Scientists have developed a new drug that targets two key regions of the tau protein, a major contributor to Alzheimer’s disease. The drug, a peptide inhibitor called RI-AG03, successfully ...

Tau tangles typically form years after the formation of another protein called amyloid, which creates plaques in the brain and is one of the first hallmarks of Alzheimer’s. The greater the ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The "mini prion" folds and stacks ...

A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein in Alzheimer's disease. Using human induced pluripotent stem cells (iPSCs) ...

The increasing knowledge on how protein tau is organized in live cells has shown that the protein forms nanometer-sized hotspots which are different from tau microtubules. These hotspots, essential ...