Scientists find a way to predict which malignant tumours will become aggressive and metastasise to other parts of the body.

Before arriving at Janelia three years ago, Postdoctoral Scientist Antonio Fiore was designing and building optical ...

New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses ...

Scientists have unlocked the mysteries of the 'extracellular matrix' which holds tumours together and the discovery could ...

Extracellular cell matrix (ECM) plays a significant role in remodeling and stiffening during breast cancer progression. The rigid ECM impedes chemotherapeutic agent penetration into tumor cells.

Scientists have developed Rhobo6, a light microscopy probe that reveals extracellular matrix structures in live tissues, ...

Researchers have developed a regenerative medicine method that successfully grafts myoblasts onto healthy muscle, boosting ...

We show here that extracellular matrix proteins interact with soluble CD95L and potentiate its pro-apoptotic activity. The cytotoxicity of supernatants from CD95L-expressing cells was increased by ...

Scientists have discovered a new way to predict which cancer tumours will become aggressive before they spread – paving the ...

Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

So far, Fiore's new direction is paying off. The extracellular matrix supports and gives structure to our cells and tissues: It provides a scaffold for cells to grow in, dictates the mechanical ...