Covalent labeling (CL) mass spectrometry is a versatile structural technique for elucidating structural information about proteins, including protein–protein complexes. When integrated with ...

Two key protein structures in the body are being visualized for the first time, thanks in part to the latest technology in the University of Cincinnati's Center for Advanced Structural Biology ...

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This final step results in 15,326 complexes covering 13,769 human proteins and consisting of 159,451 total scored protein interactions. This set of complexes, which we call the hu.MAP3.0 human protein ...

New protein-protein docking algorithm combining deep learning (AlphaFold2) and physics (Rosetta and enhanced sampling) achieves high success rates.

As this insertion became more acidic and formed an acidic dileucine motif, the protein's interaction with the AP-4 complex was strengthened, resulting in the emergence of VAMP727, a vacuole ...

Accurate modeling of protein–protein complex structures is essential for understanding biological mechanisms. Hydrogen–deuterium exchange (HDX) experiments provide valuable insights into binding ...