There is no highly effective vaccine against tuberculosis (TB), which remains an infection of global concern. Charles ...

A decades-old TB vaccine turned cancer therapy may unlock new immunotherapies by reprogramming immune cell development in the ...

This discovery highlights a previously unrecognized way antibodies can work against TB not merely by neutralizing pathogens directly, but by reshaping immune cell functions within infected tissues ...

Chinese researchers have developed an advanced, high-throughput single-cell sorting platform that enables direct isolation of living cells with targeted metabolic profiles from large mutant libraries.

"We have succeeded in chemically synthesizing the substance that occurs naturally in marine sponges in order to test its effect on tuberculosis bacteria in cell cultures. This has enabled us to ...

For this, they sorted out MR1T cells and performed single-cell RNA sequencing ... MR1-restricted T cell clonotypes are associated with "resistance" to Mycobacterium tuberculosis infection. JCI Insight ...

Time-lapse analyses of millions of antibiotic-stressed Escherichia coli characterize the diverse single-cell dynamics of persister cells that depend on antibiotics, culture conditions, and ...

Scientists who employ tissue dissociation aim to rapidly isolate high numbers of viable single cells from tissue aggregates and cellular debris with minimal damage to cell surface antigens. Obtaining ...

Analyzing the gene activity of every single bacterial cell in a colony? A new technique from Würzburg can do this much more efficiently than other methods. Not all individuals in a population of ...