A new study shows that an eight-week wild-food-only diet in a modern adult leads to dramatic, partially lasting changes in ...

This valuable study presents an analysis of evolutionary conservation in intrinsically disordered regions, identified as key drivers of phase separation, leveraging a protein language model. The ...

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

The genetic code, which controls how living things build proteins based on genetic instructions, may have developed in a ...

Natural Product Research Department, Institute for Insect Biotechnology, Justus-Liebig-University Giessen, Ohlebergsweg 12, 35392 Giessen, Germany Natural Product Department; Fraunhofer-Institute for ...

Fatty acid metabolism can affect inflammatory cytokine production ... 2 The kynurenine pathway is initiated by the oxidation of tryptophan via the enzymes IDO and TDO, with downstream catabolites ...

The team was also able to show that paralemmin-1's ability to fulfill its function depends on a single tryptophan amino acid, W54. A deeper understanding of the paralemmin protein family and MPS ...

Chromatographic conditions: Acquity UPLC HSS T3 column (1.8 μm, 2.1 × 100 mm, Waters Corporation, USA). Mobile phase A: 0.1% formic acid, Mobile phase B: 0.1% acetonitrile formate solution. The ...

In the new study, Kleinstiver’s team generated experimental PAM profiles for hundreds of engineered SpCas9 enzymes to train a neural network that related amino-acid sequence to PAM specificity.