Total neoadjuvant therapy shows promising results in routine care for advanced rectal cancer. Download PDF Copy; By Dr. Sushama R. Chaphalkar, PhD. Reviewed by Lily Ramsey, LLM Aug 26 2024.

A move toward total neoadjuvant therapy in rectal cancer has been driven by enhanced rates of therapy delivery, increased rates of pathologic response leading to potential nonoperative management ...

The authors of the OPRA trial 1 have reported on their work in neoadjuvant therapy for rectal cancer that incorporated modern practices of watch and wait into the treatment algorithm. The present ...

Effect of Total Neoadjuvant Treatment on Distant Relapse Risk. During his talk, Amatu said 26 patients achieved a complete clinical response and proceeded with nonoperative management, and 90% of ...

By Dr. Sushama R. Chaphalkar, PhD. In a recent prospective observational cohort study published in eClinicalMedicine , researchers evaluated a modified regimen of total neoadjuvant treatment (TNT ...

In recent years total neoadjuvant treatment ... Anker, C.J., et al. (2022) The Potential for Overtreatment With Total Neoadjuvant Therapy (TNT): Consider One Local Therapy Instead.

Christopher J. Anker et al, The Potential for Overtreatment With Total Neoadjuvant Therapy (TNT): Consider One Local Therapy Instead, Clinical Colorectal Cancer (2021). DOI: 10.1016/j.clcc.2021.11.001 ...

NRG-GI002: A Phase II clinical trial platform using total neoadjuvant therapy (TNT) in locally-advanced rectal cancer (LARC): Pembrolizumab experimental arm (EA) primary results.

Recruitment occurred before implementation of total neoadjuvant therapy regimens. DISCLOSURES: There was no external funding for the work. The lead investigator didn't have any disclosures.