Surgery was performed in 84% (LARCT-US) and 85% (AdmL) of patients, with an R0/R1 resection rate of 98%. Over a follow-up period of 3.6 to 7.6 years, disease-related treatment failure occurred in ...

CHICAGO — Administering modified FOLFIRINOX chemotherapy before chemoradiation, surgery and adjuvant chemotherapy improved survival outcomes of patients with locally advanced rectal cancer ...

The study concludes that consolidation chemotherapy in total neoadjuvant therapy (TNT) led to similar disease-free survival (DFS) with significantly higher organ preservation rates. Since TNT did not ...

In recent years total neoadjuvant treatment ... Anker, C.J., et al. (2022) The Potential for Overtreatment With Total Neoadjuvant Therapy (TNT): Consider One Local Therapy Instead.

Effect of Total Neoadjuvant Treatment on Distant Relapse Risk. During his talk, Amatu said 26 patients achieved a complete clinical response and proceeded with nonoperative management, and 90% of ...

Christopher J. Anker et al, The Potential for Overtreatment With Total Neoadjuvant Therapy (TNT): Consider One Local Therapy Instead, Clinical Colorectal Cancer (2021). DOI: 10.1016/j.clcc.2021.11.001 ...

THURSDAY, Aug. 22, 2024 (HealthDay News) -- Patients treated with neoadjuvant immune checkpoint inhibitor (ICI)-based therapy for hepatocellular carcinoma (HCC) have higher-risk disease features ...

NRG-GI002: A Phase II clinical trial platform using total neoadjuvant therapy (TNT) in locally-advanced rectal cancer (LARC): Pembrolizumab experimental arm (EA) primary results.