This new article publication from Acta Pharmaceutica Sinica B, discusses how the protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia–reperfusion injury by suppressing RIPK1-mediated ...

For women with inflammatory bowel disease (IBD), pregnancy can be an uncertain time due to limited clinical data about how IBD medications impact pregnancy outcomes and infants who have been exposed ...

ABSTRACT: Background: Azathioprine (AZA) remains a fundamental pharmacological agent in the treatment of chronic inflammatory bowel disease, particularly in resource-limited settings where ...

1 Hepato-Gastroenterology Department, Hassan II University Medical Center, Fez, Morocco. 2 Faculty of Medicine, Dentistry and Pharmacy, Sidi Mohammed Ben Abdellah University, Fez, Morocco. The ...

Economic evaluations of TPMT testing were identified from a systematic literature review of published studies. For the purpose of this study an economic evaluation was defined as: 'the comparative ...

1 Department of Gastroenterology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China 2 Department of Gastroenterology, Mudanjiang First People’s Hospital, Mudanjiang, China ...

2 Imperial College London, Department of Metabolism, Digestion and Reproduction, London, UK 3 Imperial College Healthcare NHS trust, Department of Gastroenterology, London, UK Introduction Thiopurines ...

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or ...

Please provide your email address to receive an email when new articles are posted on . The AGA used the GRADE framework to create 14 recommendations for the pharmacological management of moderate to ...

Participants were recruited from a single Spanish hospital. The diagnoses of IBD were made according to the Lennard-Jones criteria [30] and patients were classified in accordance with the Montreal ...

What Is the MTHFR Gene Mutation? The MTHFR gene mutation is a variation in the MTHFR gene. This gene normally tells your body how to make the MTHFR protein. You need this protein to process folate, ...

A RECENT study suggests that adding allopurinol to maintenance therapy for paediatric acute lymphoblastic leukaemia (ALL) can improve treatment outcomes and reduce toxicity, even in patients without ...