National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States ...

2013). Canonical R-M systems contain enzymes carrying out two activities: a restriction endonuclease, which binds to specific recognition sites and hydrolyzes DNA when the sequence is unmethylated, ...

Polymorphisms of thiopurine methyltransferase enzyme (TPMT) that result in low enzymatic activity have been associated with an increased risk of myelotoxicity, especially in Caucasians; however, in ...

In this study, we identify MLL4 (KMT2D) as a major mammalian H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C). Using adipogenesis and myogenesis as model ...