The field of pharmacogenetics has revealed that genetic variations, particularly in key enzymes such as thiopurine S‐methyltransferase (TPMT) and nucleotide diphosphate-linked moiety X-type ...

What is the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing of thiopurine drugs in clinical practice? Six economic models were identified and appraised.

The authors concluded that: TPMT testing for all patients receiving thiopurine drugs was cost-neutral assuming that 0.3% of patients were homozygous for mutant TPMT alleles and would experience ...

Before starting a patient on a thiopurine, the thiopurine methyltransferase enzyme activity should be assessed to correctly dose and avoid toxicity. 76 In paediatric Crohn's disease, remission rates ...

What this study adds We found that concentrations of the hepatotoxic metabolite 6-MMPN is higher during pregnancy and varies widely between patients. As in non-pregnant patients, azathioprine ...

Azathioprine and its metabolite 6-mercaptopurine (6-MP) are widely used in the treatment of Crohn’s disease, ulcerative colitis, autoimmune hepatitis, and a range of other inflammatory and autoimmune ...

THE IMPORTANCE OF TPMT The first indication that thiopurine methyltransferase (TPMT) deficiency was associated with profound myelosuppression came from observations in adults taking azathioprine as an ...

Azathioprine is a derivative of 6-mercaptopurine that interacts with cellular DNA promoting apoptosis, B-cell proliferation arrest and reduction of antibody synthesis. 83 The 6-mercaptopurine can be ...

Association of thiopurine S -methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease.

While genetic polymorphisms in key enzymes such as thiopurine S-methyltransferase (TPMT) have been well-documented as contributors to variability in thiopurine metabolism (Heckmann et al., 2005), ...

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Mechanism-Based Inhibition of an Essential Bacterial Adenine DNA Methyltransferase: Rationally Designed Antibiotics Daphne C. Wahnon , Vincent K. Shier , and Stephen J. Benkovic ...