In cell cultures, A and F together better blocked tau uptake than did A alone, and this version, dubbed VXX-301, is now being evaluated in P301L mice. The company also intends to test a multivalent ...

The toxic tau described here is actually released from neurons, so if we can figure out how to intercept it when it's floating around in the brain outside of neurons, using antibodies or other ...

Summary: New research uncovers how tau pathology spreads and damages synapses in progressive supranuclear palsy (PSP). Using ...

Preventing Tyr29 phosphorylation attenuates tau pathology, but TYK2 expression aggravates pathology in P301S mice. Credit: Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01777-2 ...

The irregular buildup of tau protein in the brain can form “tangles,” which researchers link to several brain disorders, including Alzheimer’s disease. This may have implications for ...

Tau protein in Parkinson's disease Parkinson’s disease (PD) is the second most common neurodegenerative disease, primarily characterized by the abnormal aggregation of α-synuclein (α-syn) into ...

A gene encoding a protein linked to tau production—tripartite motif protein 11 (TRIM11)—was found to suppress deterioration in small animal models of neurodegenerative diseases similar to ...

This graphene foam biosensor offers high sensitivity for tau protein detection, enabling early Alzheimer's diagnosis and ...

New research shows newborns have high levels of tau protein – linked to Alzheimer’s – without harmful effects, offering clues for future treatments.

"We found that TYK2 adds phosphate groups to tau at a particular location on the protein identified as Tyrosine 29," Kim said. "This modification stabilizes tau levels in human cells and mouse ...