Vesicle cycle model reveals inner workings of brain synapse Advanced modeling system sheds new light on the synaptic vesicle cycle, essential in human brain function Date: May 30, 2025 Source ...

Advanced modeling system sheds new light on the synaptic vesicle cycle, essential in human brain function.

How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles.

Our scientific founders have uncovered critical nuances in translating the biology of synaptic plasticity into effective therapeutics. With these proprietary insights, Syndeio is building a robust ...

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

Researchers have used cryo-electron tomography to uncover new details of the molecular structure of synaptic vesicles, which help transport neurotransmitters in the brain. The study could inform ...

Genetic variants in synaptotagmin-1 (SYT1), an essential calcium sensor that triggers action potential-evoked neurotransmitter release, cause a neurodevelopmental disorder. In vitro studies revealed ...

Given its structural similarity to SNAP-25, the SNAP-8 peptide is believed to hold potential in the field of neurobiological research. SNAP-25 is integral to synaptic vesicle fusion, a process that is ...

These processes encompass intracellular vesicle transport, neurotransmitter release, and synaptic plasticity. By disassembling the SNARE complex in an ATP-dependent manner, NSF facilitates the ...

Live imaging at single-vesicle resolution reveals rabphilin-3A as the first identified negative regulator of neuropeptide release in mammalian neurons.