Previous research has shown that aberrant sphingolipid metabolism, which is evidenced by elevated levels of circulating ceramide, is associated with poor prognosis in patients with prostate cancer (PC ...

The 80-patient placebo-controlled randomized Phase 2 study will evaluate the efficacy of opaganib in combination with Bayer's darolutamide in men with metastatic castrate-resistant ...

Here, using a yeast imaging-based screen, we identified 84 potential synphilin-1 (SY1) IB regulators and isolated the conserved sphingolipid metabolic components in the most enriched groups.

Early dysfunction of the endothelial/blood-brain barrier (BBB) is involved in the pathogenesis of cerebral small vessel disease (SVD), which is a contributor to about 50% of dementias.

Background Lymphangioleiomyomatosis (LAM) is a rare multisystem disease almost exclusively affecting women which causes loss of lung function, lymphatic abnormalities and angiomyolipomas. LAM occurs ...

Evonik will present its expanded portfolio at PCHi 2025 in Guangzhou, showcasing advanced biotechnology and products tailored to the regional mar ...

(1) SY1 aggregation enhances (in terms of number of aggregates) when Sphingolipid biosynthesis is blocked. (2) In a normal cell (where sphingolipid biosynthesis is not hampered), the aggregate of SY1 ...

He then became an HFSP Postdoctoral Fellow at the University of California, Berkeley. At Berkeley, he studied actin cytoskeleton assembly and sphingolipid biosynthesis in budding yeast. Since 2015 he ...

Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory roles in non-coding regions remain largely unclear. Using the LUHMES ...

A phase 2, multicenter, open-label study of AlloStim combined with anti-PD-L1 immunotherapy as 4L therapy in patients with MSS/pMMR metastatic colorectal cancer. This is an ASCO Meeting Abstract from ...