In this context, we will highlight select examples that exploit the Lewis acidity, organometallic reactivity and small-molecule activation modes of metal ions for chemoselective fluorescent probe ...

"The advantages of a fluorescence probe ... NIR small-molecule dye approved by the FDA for use as a contrast agent. A longer lifespan means researchers have more time to record the fluorescent ...

but show a bright fluorescent glow when treated with (S)-PHA533533, indicating that the small molecule potently activated the dormant paternal allele of UBE3A. [Vihma et. al 2024] Researchers were ...

For example, the bioactive small ... a parent molecule that would naturally bind to a protein, and the photoreactive group reacts to ultraviolet light irradiation that activates the probe.

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which ...