Knockout of Foxk2 in MuSCs results in skeletal muscle dysplasia in mice and disrupts mitochondrial homeostasis in MuSCs. CoQ10 exhibits a therapeutic effect in the mouse model.

ISS-based lab-on-a-chip model advances the understanding of muscle aging and degeneration in microgravity, guiding future therapeutic strategies.

Obesity and its associated metabolic disorders─including muscle atrophy─pose significant health challenges, particularly with the increasing prevalence of high-fat diets. This study investigates the ...

Company presented clinical and preclinical data at the MDA Conference last week in Dallas, Texas Oral presentation included data from MuSK-MG rat model depicting increases in muscle function and ...

These findings suggest that the D-gal-induced aging model is associated with a notable increase in skeletal muscle fibrosis and a high expression of IGFBP5, which may play a role in the fibrotic ...

A skeletal muscle-specific Ppm1k knockout (KO) mouse model was used to examine the effects of disrupted BCAA catabolism on sarcopenia.

Jheng et al compared findings from a skeletal muscle‐specific SIRT3 knockout mouse model with left ventricle failure model rat and patients with pulmonary hypertension (PH) associated with preserved ...

A computational model of skeletal muscle regeneration reveals complex interplay of cytokines, angiogenesis, and cell behaviors, predicting that synergistic cytokine perturbations enhance skeletal ...

Association of a clinical model based on skeletal muscle radiation attenuation with efficacy for patients with gastric cancer treated with chemotherapy plus PD-1 antibodies: A single-center ...

METHODS: Using skeletal muscle-specific Sirt3 knockout mice (Sirt3skm-/-) and mass spectrometry-based comparative secretome analysis, we attempted to define the processes by which skeletal muscle ...