in single-particle cryo-electron microscopy (cryo-EM) images. Utilizing a U-net architecture—a type of convolutional neural network renowned for its efficiency in biomedical image segmentation—our ...

These fundamental findings offer a novel mechanism by which rubrerythrin tubules encapsulate encapsulin to prevent oxidative stress in Pyrococcus furiosus. However, there are a few reasonable concerns ...

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Abstract: Single-molecule (fluorescence) localization microscopy (SMLM) finds the position of markers for target proteins at approx. 10 nm precision. Diagnosis of some diseases currently relies on ...

Biochemist Wolfgang Baumeister, director emeritus of the Max Planck Institute of Biochemistry, has received the 2025 Shaw Prize in Life Science and Medicine. The Shaw Prizes have been awarded ...

Cryogenic electron microscopy (cryo-EM) analyses of an ancient metazoan Dicer allowed capture of multiple helicase states revealing the mechanism that connects each step of ATP hydrolysis to ...

Baumeister was awarded the 2025 Shaw Prize in life science and medicine for his pioneering development and use of cryogenic electron tomography, or cryo-ET, an imaging technique that enabled 3D ...

International Center for Quantum Materials, and Electron Microscopy Laboratory, School of Physics, Peking University, Beijing 100871, China Academy for Advanced Interdisciplinary Studies, Peking ...

They then captured a high-definition 3D movie of dynein interacting with Lis1 that could represent the timeline between dynein’s Phi (locked) and Chi (unlocked) states using time-resolved cryogenic ...

states using time-resolved cryogenic electron microscopy (cryo-EM). Cryo-EM uses beams of electrons to construct a 3D image of a molecule with down-to-the-atom detail. Previous studies have used ...