So that is how defects in DNA repair can lead to increased replication stress. This, in turn, leads to things called collisions between the replication machinery and the transcription machinery ...

This study finds these bacteria as the first example of an organism using ADP-ribose modification of DNA as a mechanism for regulating gene transcription and cellular replication. The ...

In the present study, we used 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replication collisions to genome instability. After deconvoluting robust SV ...

Each strand serves two primary purposes: acting as a template during DNA replication and providing instructions for protein synthesis in a process called transcription. Replication and ...

Each strand serves two primary purposes: acting as a template during DNA replication and providing instructions for protein synthesis in a process called transcription. Replication and ...

Here, we use 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replication collisions to genome instability. After deconvoluting robust SV signatures in three ...

Based on experimentally determined average inter-origin distances of ~100 kb, DNA replication initiates from ... genomic features independently specify the origins of replication and promoters of ...

However, whether transcription plays a greater role in the organization of chromatin following DNA replication remains unclear. Here we analysed protein re-association with newly replicated DNA upon ...

causing breaks that interfere with transcription and DNA replication. The build-up of acetaldehyde in our bodies is a major contributor to some of the hangover symptoms we get after drinking.

By Carl Zimmer It has been 20 years since scientists put together the first rough draft of the human genome, the three billion genetic letters of DNA tightly wound inside most of our cells.