Guns N' Roses' Axl Rose once made a surprise appearance on 'Scooby-Doo' back in the day, and it's kind of endearing.

This year's annual Route 66 Summerfest kicks off the official start of the Route 66 Centennial Celebration.

One person has died following a major crash involving a triaxle truck that occurred along Route 66 in Westmoreland County Thursday morning.

A triaxle crashed along Route 66 in New Stanton and caught fire on Thursday. The vehicle’s hauling bed carrying asphalt, went over the barrier alongside the road and landed on a hillside.

A new exhibition at the Coconino Center for the Arts showcases real life along America's Mother Road, Route 66.

State police on Thursday arrested a man hours after they say he rammed another vehicle in Salem on Route 66, injuring four people, including one who was taken to a hospital. Cody A. Salensky, 26 ...

The crash happened early Thursday morning on Route 66 in Salem Township, near Delmont.

As Route 66 aficionados look to the historic roadway’s 100th anniversary next year, most agree there would probably not be a centennial to celebrate if not for Delgadillo.

Route 66 often conjures images of quaint small towns, but its foundation has always been rooted in Chicago.

A new art attraction is nearing completion in Collinsville, Illinois, as artist Kenzie Wolk works to finish a Route 66 mural.

Organizers plan to reveal the last design in a five-part medal series celebrating Route 66 landmarks.