Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. Alzheimer's & Dementia, 2025; 21 (6) DOI: 10.1002/alz.70322 ...

Down syndrome, which causes a range of developmental differences and affects 1 in 700 newborns in the United States, is caused by the presence of an extra copy of chromosome 21. Mongkolchon ...

Many scientists view Down’s syndrome as a genetic form of Alzheimer’s because the amyloid precursor protein (APP) gene lies on chromosome 21. The extra dose of APP in DS causes amyloid to amass in the ...

“The majority of people with Down syndrome, unfortunately, were institutionalized in this country -- many of them as infants," Whitten said. "These were by and large inhumane institutions where ...