An international research team involving the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) in Jena, the Scuola Normale Superiore Pisa, ...

This important study provides evidence for dynamic coupling between translation initiation and elongation that can help maintain low ribosome density and translational homeostasis. The authors combine ...

Protein-making slows with age, causing traffic jams in brain cells. Misfolded proteins pile up, harming memory before ...

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A study of killifish reveals how protein dysfunction develops in vertebrate brain cells, a key driver of aging – shedding ...

Aging and neurodegeneration are both known to disrupt the production of functional proteins in cells—a process called ...

The method, called ribosome profiling, delivered a surprise. On closer inspection, many of the messenger RNA molecules did not correspond to any known gene.

Translation initiation begins with the ribosome recognizing the initiation site and catalyzing the transfer of amino acids to the growing peptide chain through elongation.

The major conformations of the ribosome and the elongation cycle of translation, along with the corresponding movement parameters of the small subunit. Ribosomal translation is the process by ...