The expression of recombination-activating gene (RAG) proteins is required for the rearrangement of immunoglobulin genes and receptor editing in immature B cells in the bone marrow. However ...

The authors generated mutant mice in which the RAG proteins could interact with and bind to DNA normally without initiating V(D)J recombination and assessed RAG protein binding, as well as the ...

Described today in the journal Science Translational Medicine, the finding gives oncologists a new target for developing immunotherapies: double negative memory B cells, so-called because they are ...