High SHAPE-low Shannon regions represent stable, accessible RNAs in cells, likely exposing long Watson–Crick edges of multiple residues available for base-pairing with complementary sequences (Figure ...

Calgary, Alberta--(Newsfile Corp. - July 3, 2025) - Trican Well Service Ltd. (TSX: TCW) ("Trican") is pleased to announce that it has entered into an agreement to acquire all of the issued and ...

Researchers get viable mice by editing DNA from two sperm Altering chemical modifications of DNA lets the DNA from two sperm make a mouse.

Initially, pegRNA will bind to the target DNA sequence through complementary base pairing, following which the Cas9 nickase nicks the non-target strand.

Base-filling strategies were investigated for template-directed synthesis of recognition-encoded melamine oligomers (REMO) using H-bond base-pairing interactions between 4-nitrophenol and phosphine ...

ASOs, a type of therapeutic ON consisting of single-stranded oligonucleotides approximately 20-mer in length, selectively bind via complementary base-pairing to messenger RNA (mRNA) and are the basis ...

Ion-pairing reversed-phase liquid chromatography (IP-RPLC), a standard method to characterize small oligonucleotides, can also separate large RNA molecules. Its advantages extend beyond simple ...

That, in turn, bodes well for both the Canucks making it through this Hronek-less phase of the season, and also for the Brännström-Desharnais pairing sticking around together in the longer-term.

Lastly, RBPs can recruit molecular motors to promote mRNA transport and remote translation. miRNAs hybridize to target mRNAs via complementary base pairing, leading to the recruitment of the ...

Deep learning methods have demonstrated great performance for RNA secondary structure prediction. However, generalizability is a common unsolved issue on unseen out-of-distribution RNA families, which ...