In this important work, the authors present a new transformer-based neural network designed to isolate and quantify higher-order epistasis in protein sequences. They provide solid evidence that higher ...

He Yuan, Mou Qiang, He Yubing, Zhao Xiaoyan, Wang Jian, Zhou Guomin, Zhang Jianhua ...

A team of researchers based at the Massachusetts Institute of Technology (the United States) has tried to shed light on the inner workings of the language models that predict the structure and functio ...

Using nanopore DNA sequencing technology, researchers have managed to scan a single protein: by slowly moving a linearized protein through a tiny nanopore, one amino acid at the time, the researchers ...

Researchers link a stretch of DNA to a peptide of interest and measure current changes as the molecule is pulled by a helicase through a nanopore. Since the 1990s, nanopores have been used for ...

Stephen Fried is an associate professor in the Department of Chemistry working on misfolded proteins, which are prevalent in ...

Proteins carry out exceptionally diverse molecular functions—even though they are all built on an unvarying polyamide backbone. How much more chemical diversity might be unlocked by editing that ...

Every second of every day inside your body, proteins are made, moved, modified, and destroyed over and over again. These proteins can be short strings of amino acids or longer, intricately folded ...