Perhaps best known as a immune-system boost or antidote to scurvy, vitamin C has been found to rejuvenate aging skin by reactivating genes responsible for cell growth. By promoting DNA demethylation, ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

In this work, the researchers showed how water molecules near a protein surface can influence misfolding. A mutation that is related to tauopathies has a subtle effect on water's dynamic structure in ...

Abstract Summary Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically-diverse protein misfolding diseases.

Zhuoran Qiao has been awarded the inaugural Chen Institute and Science Prize for Al Accelerated Research for work critical to ...

The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.

Cancer researchers have discovered something remarkable hiding in plain sight: a common bacteria used to make sauerkraut and ...

Arvinas Inc. (NASDAQ:ARVN) is one of the best low priced pharma stocks to buy now. Earlier on June 13, Arvinas presented ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Background The elimination of HBV covalently closed circular DNA (cccDNA) remains a critical hurdle for chronic hepatitis B (CHB) management. Objective In this investigation, we examined the efficacy ...