The general pattern that emerges in all these diseases is an abnormal tendency of proteins to aggregate as a result of misfolding. The aggregation can be caused by chance; by protein ...

The discovery of this new function for a key enzyme in cell biology could lead to new therapeutic approaches for Alzheimer's and other protein-misfolding diseases. An interdisciplinary team of ...

the scientists also uncovered new insights into the role of water around the protein surface that guides the misfolding process. A mutation commonly used to model tau-related diseases subtly ...

New drugs are actively being sought for the treatment of neurodegenerative diseases related to protein misfolding and aggregation. In clinical trials, there is a big need for translatable ...

Misfolding of the prion protein triggers prion diseases such as Creutzfeldt-Jakob disease. All research findings to date indicate that the misfolded prion protein acquires toxic activity.

potentially we can come up with a therapeutic for blindness and other protein-misfolding diseases.” Purdue University is a public research university leading with excellence at scale. Ranked among top ...

Neurodegenerative diseases, ranging from Alzheimer's to prion diseases, exhibit protein misfolding and deposits in the brain. While it's established that misfolded proteins contribute to these ...

Misfolding of the prion protein triggers prion diseases such as Creutzfeldt-Jakob disease. All research findings to date indicate that the misfolded prion protein acquires toxic activity.