New computer simulations that model every atom of a protein as it folds into its final three-dimensional form support the ...

Protein Conformation and the Concept of Misfolding For many proteins, the most prominent structural motif of the functional protein in its native conformation is known as the alpha helix, a right ...

New computer simulations that model every atom of a protein as it folds into its final three-dimensional form support the ...

Future directions and challenges in protein misfolding research New drugs are actively being sought for the treatment of neurodegenerative diseases related to protein misfolding and aggregation.

Proteins misfolding and clumping together, a process known as aggregation, is a key feature seen in several neurological conditions, including Alzheimer's and Parkinson's diseases. These ...

The good news: Coles is pairing with renowned protein-misfolding expert Susan Lindquist of the Massachusetts Institute of Technology's Whitehead Institute to tackle a meaty problem that affects ...

First synthetic 'mini prion' shows how protein misfolding multiplies Model enables study of fundamental interactions underlying neurodegenerative disease Date: April 30, 2025 Source: Northwestern ...

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in protein synthesis and folding. Previous studies have shown that protein ...

Prion diseases are characterized by abnormal folding of the host’s naturally-occurring prion protein, leading to rapid neurodegeneration. They can be genetic, sporadic—without known cause—or acquired, ...

Gain plans to initiate Phase 1 clinical trials evaluating GT-02287 for Parkinson's disease in 2023. It would be the first treatment to target protein misfolding underpinning the disease if successful.

Proteins misfolding and clumping together, a process known as aggregation, is a key feature seen in several neurological conditions, including Alzheimer's and Parkinson's diseases. These disorders ...