The general pattern that emerges in all these diseases is an abnormal tendency of proteins to aggregate as a result of misfolding. The aggregation can be caused by chance; by protein ...

the scientists also uncovered new insights into the role of water around the protein surface that guides the misfolding process. A mutation commonly used to model tau-related diseases subtly ...

Misfolding of the prion protein triggers prion diseases such as Creutzfeldt-Jakob disease. All research findings to date indicate that the misfolded prion protein acquires toxic activity.

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell's main energy currency, ...

The discovery of this new function for a key enzyme in cell biology could lead to new therapeutic approaches for Alzheimer's and other protein-misfolding diseases. An interdisciplinary team of ...

New drugs are actively being sought for the treatment of neurodegenerative diseases related to protein misfolding and aggregation. In clinical trials, there is a big need for translatable ...

potentially we can come up with a therapeutic for blindness and other protein-misfolding diseases.” Purdue University is a public research university leading with excellence at scale. Ranked among top ...

A spectrum of neurodegenerative diseases, including frontotemporal ... sites along the long form of mutated tau, preventing the misfolding and spreading of the neurofibrillary tangles.

The general pattern that emerges in all these diseases is an abnormal tendency of proteins to aggregate as a result of misfolding. The aggregation can be caused by chance; by protein ...

Misfolding of the prion protein triggers prion diseases such as Creutzfeldt-Jakob disease. All research findings to date indicate that the misfolded prion protein acquires toxic activity.