This important study presents a compelling theoretical framework for understanding phase separation of membrane-bound proteins, with a focus on the organization of tight junction components. By ...

Nucleoside reverse transcriptase inhibitor; PI: Protease inhibitor; PK: Pharmacokinetics; RPV: Rilpivirine. Data taken from [10,33–38]. Blake Max's spouse is employed as a regional medical ...

In 2016, the FDA approved Merck & Co’s fixed-dose combination of the NS5A inhibitor elbasvir plus its NS3/4A protease inhibitor grazoprevir (Zepatier) for chronic hepatitis C virus. In 2020 ...

After the failure of first-line NNRTI-based ART, guidelines recommend an anchor drug from a new class (a ritonavir-boosted protease inhibitor or integrase inhibitor), plus a backbone of two ...

This fundamental study combines in vitro reconstitution experiments and molecular dynamics simulations to elucidate how membrane lipids are transported from the outer to the inner membrane of ...

Together, they have reimagined the iconic London Tube map to shed light on the music venues and iconic artists from the city. At time of writing, there are 179 grassroots music spaces in the ...

A power outage caused major travel disruption on London's Tube network on Monday, stretching into rush hour. The Elizabeth, Bakerloo, Jubilee and Northern lines were among the routes either ...

The influence of the drug entinostat, a so-called HDAC inhibitor that is currently undergoing clinical trials, was investigated in the mouse model. The pharmacological blockade of HDAC activity ...

The two new compounds – LSD1 inhibitor EXS74539 and MALT1 protease inhibitor EXS73565 – both hit targets in cancer that have proved challenging for other drug developers, mainly as a result of ...

NEW YORK, May 14, 2025--(BUSINESS WIRE)--Schrödinger, Inc. (Nasdaq: SDGR) today announced that initial Phase 1 clinical data for SGR-1505, its investigational MALT1 inhibitor, will be presented ...

I have a 3 year old Triangle Tube Solo Instinct and have had nothing but problems for 2 years. I’ve had several boiler experts look at it and No one can determine ...